| East Carolina Pirates vs. Appalachian State Mountaineers | East Carolina Pirates vs. Appalachian State Mountaineers | Dowdy-Ficklen Stadium | Dowdy-Ficklen Stadium
Greenville, NC | 09/01/2012 3:30 AM | Sep 01, 2012 TBA | View Tickets |
| South Carolina Gamecocks vs. East Carolina Pirates | South Carolina Gamecocks vs. East Carolina Pirates | Williams-Brice Stadium | Williams-Brice Stadium
Columbia, SC | 09/08/2012 3:30 AM | Sep 08, 2012 TBA | View Tickets |
| Southern Miss Golden Eagles vs. East Carolina Pirates | Southern Miss Golden Eagles vs. East Carolina Pirates | M. M. Roberts Stadium | M. M. Roberts Stadium
Hattiesburg, MS | 09/15/2012 3:30 AM | Sep 15, 2012 TBA | View Tickets |
| North Carolina Tar Heels vs. East Carolina Pirates | North Carolina Tar Heels vs. East Carolina Pirates | Kenan Stadium | Kenan Stadium
Chapel Hill, NC | 09/22/2012 3:30 AM | Sep 22, 2012 TBA | View Tickets |
| East Carolina Pirates vs. UTEP Miners | East Carolina Pirates vs. UTEP Miners | Dowdy-Ficklen Stadium | Dowdy-Ficklen Stadium
Greenville, NC | 09/29/2012 3:30 AM | Sep 29, 2012 TBA | View Tickets |
| UCF Golden Knights vs. East Carolina Pirates | UCF Golden Knights vs. East Carolina Pirates | Bright House Networks Stadium | Bright House Networks Stadium
Orlando, FL | 10/04/2012 3:30 AM | Oct 04, 2012 TBA | View Tickets |
| East Carolina Pirates vs. Memphis Tigers | East Carolina Pirates vs. Memphis Tigers | Dowdy-Ficklen Stadium | Dowdy-Ficklen Stadium
Greenville, NC | 10/13/2012 3:30 AM | Oct 13, 2012 TBA | View Tickets |
| East Carolina Pirates vs. Navy Midshipmen | East Carolina Pirates vs. Navy Midshipmen | Dowdy-Ficklen Stadium | Dowdy-Ficklen Stadium
Greenville, NC | 10/27/2012 3:30 AM | Oct 27, 2012 TBA | View Tickets |
| East Carolina Pirates vs. Houston Cougars | East Carolina Pirates vs. Houston Cougars | Dowdy-Ficklen Stadium | Dowdy-Ficklen Stadium
Greenville, NC | 11/03/2012 3:30 AM | Nov 03, 2012 TBA | View Tickets |
| Tulane Green Wave vs. East Carolina Pirates | Tulane Green Wave vs. East Carolina Pirates | Mercedes-Benz Superdome (formerly Louisiana Superdome) | Mercedes-Benz Superdome (formerly Louisiana Superdome)
New Orleans, LA | 11/17/2012 3:30 AM | Nov 17, 2012 TBA | View Tickets |
| East Carolina Pirates vs. Marshall Thundering Herd | East Carolina Pirates vs. Marshall Thundering Herd | Dowdy-Ficklen Stadium | Dowdy-Ficklen Stadium
Greenville, NC | 11/24/2012 3:30 AM | Nov 24, 2012 TBA | View Tickets |